Gestational DM Pathophysiology and Epidemiology

Gestational DM
Pathophysiology and Epidemiology

F. Hosseinpanah

Obesity Research Center

Research Institute for Endocrine sciences

Shahid Beheshti University

of Medical Sciences

January19,2012

Tehran

Outline

• Brief review of pathophysiology
• Risk factors of GDM
• Reported prevalence in Iran
• Trend of obesity in Iran
• Impact of new criteria on prevalence of GDM
• Conclusion

Early pregnancy

• Increased glucose-stimulated insulin secretion
• Unchanged or enhanced peripheral (muscle) insulin sensitivity
• Unchanged basal hepatic glucose production
• Normal or slightly improved glucose tolerance
• Normal sensitivity to the blood glucose–lowering effect of exogenously administered insulin